منابع مشابه
Binding of acrylonitrile to parvalbumin.
A previous study has shown that acrylonitrile (ACN) has a long half-life in rainbow trout muscle and that [14C]ACN appears to be bound to a 10,000-Da protein in muscle. The labeled protein was purified from muscle of trout exposed to [14C]ACN, separated on 20% SDS-PAGE, and digested for amino acid analysis and sequence analysis. These studies indicated that the labeled protein was the Ca(2+)-bi...
متن کاملLuminescence studies of lanthanide ion binding to parvalbumin.
Luminescence methods were used to examine the interaction of Eu(III) and Tb(III) with parvalbumin isozyme III from pike (Esox lucius). The bound lanthanide ions were excited both directly, via laser irradiation, and indirectly, via fluorescence energy transfer from adjacent phenylalanine residues. At high (175 microM) protein concentrations, the lanthanide titration curves exhibited pronounced ...
متن کاملEngineering Parvalbumin for the Heart: Optimizing the Mg2+ Binding Properties of Rat β-Parvalbumin
Parvalbumin (PV), an EF-hand protein family member, is a delayed calcium buffer that exchanges magnesium for calcium to facilitate fast skeletal muscle relaxation. Genetic approaches that express parvalbumin in the heart also enhance relaxation and show promise of being therapeutic against various cardiac diseases where relaxation is compromised. Unfortunately, skeletal muscle PVs have very slo...
متن کاملDigestibility and IgE-Binding of Glycosylated Codfish Parvalbumin
Food-processing conditions may alter the allergenicity of food proteins by different means. In this study, the effect of the glycosylation as a result of thermal treatment on the digestibility and IgE-binding of codfish parvalbumin is investigated. Native and glycosylated parvalbumins were digested with pepsin at various conditions relevant for the gastrointestinal tract. Intact proteins and pe...
متن کاملThe Calcium-binding protein parvalbumin modulates the firing
5 The Reticular Thalamic Nucleus (RTN) of the mouse is characterized by an overwhelming majority of 6 GABAergic neurons receiving afferences from both the thalamus and the cerebral cortex and sending projections 7 mainly on thalamo-cortical neurons. The RTN neurons express high levels of the “slow Ca2+ buffer” parvalbu8 min (PV) and are characterized by low-threshold Ca2+ currents, IT. We perfo...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 1996
ISSN: 1096-6080,1096-0929
DOI: 10.1093/toxsci/29.2.260